Omega-3 fatty acids: A new key to longevity and the health of our organs?

The issue of aging and maintaining health is an increasingly relevant topic not only in medicine but throughout society. The growing number of seniors has led to increased interest in ways to slow the aging process and extend a high-quality, active life. Recent studies are increasingly focusing on the role of mitochondria – the energy centers of cells – and their key role in the aging process. Research in recent years shows that one of the most effective tools we can use to protect and restore mitochondrial health is omega-3 fatty acids, especially eicosapentaenoic acid (EPA).

Mitochondria as the Center of Longevity

To understand the impact of omega-3 fatty acids, it is essential to recognize how important mitochondria are for our body. These cellular organelles are responsible for producing most of the cell's energy in the form of ATP (adenosine triphosphate). As we age, mitochondria become damaged, leading to an energy imbalance, increased production of free radicals, and subsequent damage to cells, organs, and the entire organism. This condition is associated with many chronic diseases, such as cardiovascular diseases, diabetes, neurodegenerative disorders, and cancer.

Omega-3 Fatty Acids and Their Impact on Energy Metabolism

A recent study published in the journal Pharmacological Research provided important evidence on how omega-3 fatty acids, especially EPA, can help slow aging by enhancing mitochondrial metabolism. This study demonstrated that EPA acts as a natural agonist of the PPARα receptor (peroxisome proliferator-activated receptor alpha), which is key for fatty acid oxidation (FAO). Activation of this receptor significantly promotes fatty acid burning, increasing ATP production and reducing unwanted lipid accumulation in cells.

Research on mice confirmed that regular administration of EPA significantly improved the energy status of organs such as the heart, liver, lungs, kidneys, and brain. EPA also reduced inflammatory processes and minimized pathological changes characteristic of aging organs – including fibrosis, hypertrophy, cellular senescence, and the accumulation of neurodegenerative proteins.

Fat-1 Transgenic Mice: Endogenous Omega-3 Production and Protection Against Aging

A significant breakthrough was also the experiment with transgenic mice carrying the fat-1 gene, which enables the conversion of omega-6 fatty acids into omega-3 directly within the organism. These mice exhibited markedly better health parameters and slowed signs of aging, including improved heart function, reduced blood pressure, lower inflammation, and better metabolic values. The study's results also showed that endogenously produced omega-3 fatty acids act as an effective prevention against aging and chronic diseases.

Optimizing the Omega-6 and Omega-3 Balance

One of the key findings of this study was that the balance between omega-6 and omega-3 fatty acids plays a crucial role in the aging process. The results showed that this balance is disrupted with age, leading to increased inflammation and metabolic imbalance. Regular supplementation with EPA significantly reduces the omega-6 to omega-3 ratio, which is associated with better health and slower organ aging.

Practical Recommendation: Preventing Aging with Omega-3 Fatty Acids

Based on these results, we can practically recommend the regular use of omega-3 fatty acids, especially EPA, as an effective strategy to slow aging and protect mitochondrial health. The best natural sources of omega-3 fatty acids are wild fatty sea fish (e.g., salmon, sardines, mackerel) or high-quality krill oil, such as that from ENDALA. Krill oil is easily absorbed and contains omega-3 fatty acids in a natural and highly effective form.

Quality supplementation, optimizing a diet rich in omega-3 fatty acids, minimizing omega-6 fatty acid intake, and regular physical activity can significantly contribute to protecting mitochondrial health and promoting longevity.

Scientific progress shows us that longevity is not just a matter of genetics but can be significantly influenced by lifestyle and nutrition. Omega-3 fatty acids are now one of the most effective tools available to protect health, prevent chronic diseases, and slow down the aging process. It is up to us how we use this knowledge for a healthier and better quality of life.

https://www.sciencedirect.com/science/article/pii/S1043661824003293?ref=pdf_download&fr=RR-2&rr=943b289c5f5f3516