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Article: Adrenal Fatigue: A Complex Problem Rooted in the Brain

Adrenální únava: Komplexní problém s kořeny v mozku

Adrenal Fatigue: A Complex Problem Rooted in the Brain


Adrenal fatigue is a condition that has been attracting more and more attention recently. It is manifested by chronic fatigue, insomnia, digestive problems, mood swings and other non-specific symptoms. Many sources state that the primary cause is reduced adrenal function. But the reality is more complicated. Adrenal fatigue is essentially a brain problem, specifically impaired signaling in the paraventricular nucleus (PVN) of the hypothalamus. If we want to effectively treat this condition, we must focus on the causes in the central nervous system.

What is the paraventricular nucleus and what is its function?

The paraventricular nucleus (PVN) is a key region of the hypothalamus that connects the nervous, endocrine, and immune systems. It functions as a central office that receives signals from various parts of the body and, based on them, controls the activity of important organs, including the adrenal glands. If the function of the PVN is impaired, there is an imbalance in the entire organism, which manifests itself externally, among other things, as adrenal fatigue.

Symptoms of impaired PVN function

PVN dysfunction can manifest in a variety of ways. The most common symptoms include:
- Chronic fatigue and exhaustion
- Insomnia and poor quality sleep
- Digestive problems such as bloating, diarrhea or constipation
- Mood swings, depression, anxiety
- Memory and concentration disorders
- Headaches and migraines
- Reactive hypoglycemia

Causes of Adrenal Fatigue

The main cause of impaired signaling in the PVN is an inappropriate lifestyle. This includes stress, lack of sleep, improper diet, lack of exercise and other factors. An important role is played by the hormone leptin, which provides the brain with information about the body's energy state.
Leptin is produced by fat cells and its level changes according to food intake - it decreases during starvation and increases during overeating. It therefore serves as a signal of energy availability. However, if leptin signaling is disrupted for a long time (for example, by consuming a large amount of sugar and industrially processed foods), this gradually leads to damage to the PVN and the development of adrenal fatigue.

Effect of blue light on leptin

Newer research shows that light, especially its blue component, has an effect on leptin production and signaling. Exposure to blue light in the evening disturbs the natural nocturnal production of the hormone melatonin. At the same time, it plays an important role in the regulation of leptin.
If we are long-term exposed to blue light from artificial sources (such as computer screens, tablets, mobile phones or LED bulbs), nighttime leptin secretion is suppressed. This disrupts one of the key signals that the brain uses to evaluate the body's energy balance. The consequence is again the weakening of the activity of the PVN and the development of symptoms of adrenal fatigue.

Influence of circadian rhythms

The activity of the PVN and the entire organism is controlled by circadian rhythms - cycles of wakefulness and sleep that repeat approximately every 24 hours. These rhythms are controlled by specialized "clocks" in the brain (suprachiasmatic nuclei) and influenced by external signals, especially the alternation of light and darkness.
Modern times have brought with them artificial lighting and an excess of blue light emitted by electronic screens. This light, if we are exposed to it in the evening, disrupts the natural production of melatonin and thus throws off our internal clock. The result is worse falling asleep, poor quality sleep and other problems.
The solution can be a special CLOCK 3 in 1 biodynamic bulb. It can faithfully imitate natural daylight and thus supports healthy circadian rhythms. The CLOCK 3 in 1 bulb offers three lighting modes:
1. Daylight - stimulating, suitable for the active part of the day
2. Morning and Evening light - soothing, without the blue component that disrupts the production of melatonin
3. Night light - muted red light that does not disturb sleep even during night trips to the toilet
The use of CLOCK 3 in 1 biodynamic lighting can significantly contribute to the restoration of natural circadian rhythms and thus to the treatment of adrenal fatigue.
Circadian disturbances can lead to the development of adrenal fatigue because the PVN works closely with the suprachiasmatic nuclei and its function is dependent on the correct timing of signals. If our internal clock is permanently out of tune, this will gradually affect the health of the adrenal glands.

Influence of alcohol

Alcohol is another factor that can contribute to the development of adrenal fatigue. The ethanol contained in alcoholic beverages suppresses the activity of the PVN and disrupts the delicate interplay of the autonomic nervous system.
Regular consumption of alcohol, even in small doses, chronically burdens our regulatory mechanisms and leads to their failure. The brain stops responding adequately to the load and the organism finds itself in a state of permanent stress, even though we may not be fully aware of it.

Diagnosis of adrenal fatigue

Adrenal fatigue cannot be reliably diagnosed with common blood tests. Adrenal function tests (such as the salivary cortisol test) are also not completely conclusive because they do not reveal the primary cause of the problems - dysfunction at the brain level.
For a correct diagnosis, a comprehensive view and evaluation of all symptoms, lifestyle and other factors is needed. The clue can be, for example, an increased level of pro-inflammatory cytokines, reduced heart rate variability or a disturbed circadian rhythm of hormone production.
A very useful method is the continuous five-day measurement with the Firstbeat system. This technology uses a special chest strap with ECG sensors that records heart activity in real time. A number of valuable indicators can then be derived from the measured data:
- Level of stress and recovery during the day and night
- Quality and depth of sleep
- Share of individual sleep phases (REM, deep sleep...)
- The overall level of regeneration of the organism
- Training load and exercise efficiency
Five-day monitoring can also reveal hidden disorders of the autonomic nervous system, which are the basis of adrenal fatigue. The data obtained are a valuable guide for directing treatment and modifying lifestyle. Repeated measurement after 3-6 months will allow an objective evaluation of the effectiveness of the chosen measures.

Adrenal Fatigue Treatment

In the treatment of adrenal fatigue, the focus should be on restoring the proper function of the PVN and the entire brain. Lifestyle modification is key:
1. A healthy diet based on the principle of Real, Local and Seasonal foods. These foods naturally contain the most nutrients and the least toxins. The emphasis should be on sufficient quality proteins, healthy fats and vegetables. On the contrary, it is advisable to limit sugars, industrially processed foods and potential allergens.
2. Regular sleep of sufficient length and quality, supported by proper sleep hygiene. Limiting exposure to blue light in the evening, for example by using the CLOCK 3-in-1 biodynamic bulb or wearing blue-blocking glasses.
3. Coping with stress using relaxation techniques, meditation, adequate physical activity.
4. Support of circadian rhythms by proper timing of food, sleep and light exposure. Limitation of alcohol consumption.
For targeted support of adrenal function, it is advisable to include the product NERVY. It contains a carefully selected combination of B vitamins, magnesium and adaptogenic herbs (ginseng, eleutherococcus), which nourish the nervous system and strengthen resistance to stress. Regular use of NERVY can therefore speed up the regeneration of the adrenal glands and reduce the symptoms of adrenal fatigue.
As additional means, you can use KLID AND SLEEP products, which specifically nourish the individual branches of the autonomic nervous system, i.e. sympathetic and parasympathetic.
Psychotherapy is also important, which helps to process accumulated stress, learn to manage stressful situations more healthily and generally supports brain regeneration.


Adrenal fatigue is a complex condition, the real cause of which is impaired signaling in the brain, not just adrenal dysfunction. Disruption of circadian rhythms, excess blue light (which disrupts leptin secretion) and alcohol consumption play a significant role here.
During diagnosis, it is very beneficial to use the continuous five-day measurement by the Firstbeat system, which can reveal hidden disorders of the autonomic nervous system and provide valuable clues for directing treatment.
As part of the therapy, it is necessary to focus on restoring the proper functioning of the central nervous system, especially the paraventricular nucleus of the hypothalamus. The key to success is lifestyle modification, which includes a diet based on the principle of Real, Local and Seasonal foods, quality sleep (supported by using the CLOCK 3 in 1 biodynamic bulb), stress management and support of natural biorhythms. For targeted nutrition of the adrenal glands and the nervous system, it is advisable to use NERVY. In addition, the autonomic nervous system can be supported with the products KLID AND SLEEP.
If we manage to restore the healthy function of the brain, this will have a positive effect on the entire organism and the symptoms of adrenal fatigue will gradually disappear. It is a long-distance race that requires patience and determination. But the result will be a fundamental improvement of health, quality of life and overall resistance to the onslaughts of modern times.​​​​​​​​​​​​​​

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